Medical Genetics
What is Familial Mediterranean Fever (FMF)?
FMF is an autoinflammatory disease caused by mutations in the MEFV gene. It is especially prevalent in Turkish, Armenian, Arab, and Jewish populations.
FMF Epidemiology in Turkey
- Carrier rate: ~20% (1 in 5 people)
- Patient prevalence: ~1/1000
- Most common mutations: M694V, M680I, V726A, E148Q
- Inheritance: Autosomal recessive
Allelyn's MEFV/FMF Support
Allelyn integrates the INFEVERS database with 64 genes and 3,100+ variants for automatic screening. MEFV variants are automatically detected, cross-validated with ClinVar, and reported in the clinical report.
Clinical Impact
Early diagnosis and treatment of FMF (colchicine) prevents serious complications like amyloidosis. With Allelyn, MEFV screening is completed in under 45 minutes.